Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump-Reference-Cited by-同舟云学术

Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump

Published:2016-11-02 Issue:1 Volume:3 Page:89-98
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Abdali Narges¹,Parks Jerry M.²³,Haynes Keith M.⁴,Chaney Julie L.¹,Green Adam T.²,Wolloscheck David¹,Walker John K.⁴,Rybenkov Valentin V.¹,Baudry Jerome²³,Smith Jeremy C.²³,Zgurskaya Helen I.¹

Affiliation:

1. Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States

2. UT/ORNL Center for Molecular Biophysics, Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States

3. Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, United States

4. Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri 63104, United States

Funder

National Institute of Allergy and Infectious Diseases

Oklahoma Center for the Advancement of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.6b00167

Reference45 articles.

1. Structure of the AcrAB–TolC multidrug efflux pump

2. Pseudoatomic Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Reveals the Intermeshing Cogwheel-like Interaction between AcrA and TolC

3. Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli

4. Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli

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