Structure–Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay-Reference-Cited by-同舟云学术

Structure–Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay

Published:2019-02-05 Issue:4 Volume:5 Page:641-651
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Lee Minhee¹,Zhao Jinshi²,Kwak Seung-Hwa¹,Cho Jae²,Lee Myungju³,Gillespie Robert A.²,Kwon Do-Yeon¹,Lee Hyunji¹^ORCID,Park Hyun-Ju⁴^ORCID,Wu Qinglin²,Zhou Pei²^ORCID,Hong Jiyong¹^ORCID

Affiliation:

1. Department of Chemistry, Duke University, 124 Science Drive, Box 90346, Durham, North Carolina 27708, United States

2. Department of Biochemistry, Duke University Medical Center, Box 3711, Durham, North Carolina 27710, United States

3. College of Pharmacy, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea

4. School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea

Funder

U.S. Department of Health and Human Services

Duke University

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.8b00364

Reference27 articles.

1. WHO Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics; World Health Organization, 2017.

2. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

3. Lipopolysaccharide Endotoxins

4. Mechanism and Inhibition of LpxC: An Essential Zinc-Dependent Deacetylase of Bacterial Lipid A Synthesis

5. Structure, inhibition, and regulation of essential lipid A enzymes

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