Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics

Author:

Tyagi Rahul1,Maddirala Amarendar Reddy2,Elfawal Mostafa3,Fischer Chelsea4,Bulman Christina A.4,Rosa Bruce A.1,Gao Xin1,Chugani Ryan2,Zhou Mingzhou2,Helander Jon2,Brindley Paul J.5,Tseng Chih-Chung6,Greig Iain R.6,Sakanari Judy4,Wildman Scott A.7ORCID,Aroian Raffi3,Janetka James W.2,Mitreva Makedonka18ORCID

Affiliation:

1. McDonnell Genome Institute, Washington University School of Medicine, 4444 Forest Park Ave., St. Louis, Missouri 63108, United States

2. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Missouri 63110, United States

3. University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, United States

4. Department of Pharmaceutical Chemistry, University of California San Francisco, 1700 4th Street, San Francisco, California 94158, United States

5. Department of Microbiology, Immunology & Tropical Medicine and Research Center for Neglected Diseases of Poverty, School of Medicine and Health Sciences, George Washington University, 2300 Eye Street, NW, Washington, D.C. 20037, United States

6. Kosterlitz Centre for Therapeutics, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, United Kingdom

7. UW Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, 1111 Highland Ave., Madison, Wisconsin 53792, United States

8. Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, 4523 Clayton Ave., St. Louis, Missouri 63110, United States

Funder

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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