A Computationally Designed Peptide Derived from Escherichia coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies

Author:

Cardoso Marlon H.1234,Cândido Elizabete S.23,Chan Lai Y.4,Der Torossian Torres Marcelo567,Oshiro Karen G. N.13,Rezende Samilla B.3,Porto William F.238,Lu Timothy K.56ORCID,de la Fuente-Nunez Cesar56,Craik David J.4ORCID,Franco Octávio L.123ORCID

Affiliation:

1. Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, Campus Darcy Ribeiro, Asa Norte, Brasília, DF 70910900, Brazil

2. Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, SGAN 916 Módulo B, Asa Norte, Brasília, DF 70790160, Brazil

3. S-inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco Avenida Tamandaré 6000, Campo Grande, MS 79117900, Brazil

4. Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, Brisbane, QLD 4072, Australia

5. Synthetic Biology Group, MIT Synthetic Biology Center; The Center for Microbiome Informatics and Therapeutics; Research Laboratory of Electronics, Department of Biological Engineering, and Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

6. Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, United States

7. Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, SP 09210170, Brazil

8. Porto Reports, Brasília, DF 70790160, Brazil

Funder

Funda??o de Apoio ? Pesquisa do Distrito Federal

Fundaci?n Ram?n Areces

Australian Research Council

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

Funda??o de Apoio ao Desenvolvimento do Ensino, Ci?ncia e Tecnologia do Estado de Mato Grosso do Sul

Defense Threat Reduction Agency

Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior

Advance Queensland Women?s Academic Fund, University of Queensland

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Reference45 articles.

1. Persistent bacterial infections and persister cells

2. A brief history of antibiotics and select advances in their synthesis

3. World Health Organization (2017) Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics, https://www.who.int/medicines/publications/global-priority-list-antibiotic-resistant-bacteria/en/.

4. Bacterial biofilms: from the Natural environment to infectious diseases

5. Designing antimicrobial peptides: form follows function

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