Fast-Acting Small Molecules Targeting Malarial Aspartyl Proteases, Plasmepsins, Inhibit Malaria Infection at Multiple Life Stages

Author:

Singh Snigdha12,Rajendran Vinoth3,He Jiang4,Singh Amit K.2,Achieng Angela O.5,Vandana 6,Pant Akansha6,Nasamu Armiyaw S.7,Pandit Mansi8,Singh Jyoti9,Quadiri Afshana9,Gupta Nikesh10,Poonam 11,Ghosh Prahlad C.3,Singh Brajendra K.2,Narayanan Latha8,Kempaiah Prakasha512,Chandra Ramesh2,Dunn Ben M.13,Pandey Kailash C.614,Goldberg Daniel E.7,Singh Agam P.9,Rathi Brijesh115ORCID

Affiliation:

1. Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College University Enclave, University of Delhi, Delhi 110007, India

2. Department of Chemistry, University of Delhi, Delhi 110007, India

3. Department of Biochemistry, University of Delhi South Campus, New Delhi 110021, India

4. Institute for Medical Engineering and Science, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

5. Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States

6. Host−Parasite Interaction Biology Group, National Institute of Malaria Research, Lab. No. 219, Sector-8 Dwarka, New Delhi 110077, India

7. Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, United States

8. Bioinformatics Infrastructure Facility, Sri Venkateswara College, University of Delhi South Campus, New Delhi 110021, India

9. Infectious Diseases Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India

10. Special Centre for Nanosciences, Jawaharlal Nehru University, New Delhi 110067, India

11. Department of Chemistry, Miranda House, University of Delhi North Campus, Delhi 110007, India

12. Department of Medicine, Loyola University Stritch School of Medicine, 2160 South First Avenue, Chicago, Illinois 60153, United States

13. Department of Biochemistry & Molecular Biology, University of Florida College of Medicine, P.O. Box 100245, Gainesville, Florida 32610, United States

14. Department of Biochemistry, National Institute for Research in Environmental Health, ICMR, Bhopal 462001, India

15. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Funder

University Grants Commission

Science and Engineering Research Board

National Institute of Allergy and Infectious Diseases

Department of Biotechnology , Ministry of Science and Technology

Department of Science and Technology, Ministry of Science and Technology

National Institute of Immunology

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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