Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target-Reference-Cited by-同舟云学术

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Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target

Published:2017-05-04 Issue:7 Volume:3 Page:527-541
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

de Villiers Marianne¹,Spry Christina,Macuamule Cristiano J.¹,Barnard Leanne¹,Wells Gordon¹,Saliba Kevin J.,Strauss Erick¹^ORCID

Affiliation:

1. Department of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa

Funder

Department of Health, Australian Government

Department of Science and Technology, Republic of South Africa

National Research Foundation

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.7b00024

Reference53 articles.

1. Novel pantothenate derivatives for anti-malarial chemotherapy

2. A Pantetheinase-Resistant Pantothenamide with Potent, On-Target, and Selective Antiplasmodial Activity

3. Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity

4. Pantothenamides Are Potent, On-Target Inhibitors of Plasmodium falciparum Growth When Serum Pantetheinase Is Inactivated

5. Structural Modification of Pantothenamides Counteracts Degradation by Pantetheinase and Improves Antiplasmodial Activity

Cited by 28 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA;Open Research Africa;2023-10-19

2. Starving the Beast: Limiting Coenzyme A Biosynthesis to Prevent Disease and Transmission in Malaria;International Journal of Molecular Sciences;2023-09-10

3. Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA;Open Research Africa;2023-03-07

4. Recent metabolomic developments for antimalarial drug discovery;Parasitology Research;2022-10-04

5. Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA;Open Research Africa;2022-08-19

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