Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action
Author:
Affiliation:
1. Department of Biochemistry, Stellenbosch University, Private Bag X1, Matieland, 7602, South Africa
2. Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland, 7602, South Africa
Funder
National Research Foundation
Publisher
American Chemical Society (ACS)
Subject
Infectious Diseases
Link
https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.7b00240
Reference30 articles.
1. Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development
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3. Coenzyme A Biosynthesis and Enzymology
4. Coenzyme A biosynthesis: an antimicrobial drug target
5. Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis
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