Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions

Author:

Ginn John1,Jiang Xiuju,Sun Shan1,Michino Mayako1,Huggins David J.1ORCID,Mbambo Zodwa,Jansen Robert,Rhee Kyu Y.,Arango Nancy2,Lima Christopher D.23ORCID,Liverton Nigel1,Imaeda Toshihiro1,Okamoto Rei1,Kuroita Takanobu1,Aso Kazuyoshi1,Stamford Andrew1,Foley Michael1,Meinke Peter T.1,Nathan Carl,Bryk RuslanaORCID

Affiliation:

1. Tri-Institutional Therapeutics Discovery Institute, New York, New York 10065, United States

2. Structural Biology Program, Sloan Kettering Institute, New York, New York 10065, United States

3. Howard Hughes Medical Institute, New York, New York 10065, United States

Funder

National Cancer Institute

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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