Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions-Reference-Cited by-同舟云学术

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Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions

Published:2021-02-02 Issue:2 Volume:7 Page:435-444
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Ginn John¹,Jiang Xiuju,Sun Shan¹,Michino Mayako¹,Huggins David J.¹^ORCID,Mbambo Zodwa,Jansen Robert,Rhee Kyu Y.,Arango Nancy²,Lima Christopher D.²³^ORCID,Liverton Nigel¹,Imaeda Toshihiro¹,Okamoto Rei¹,Kuroita Takanobu¹,Aso Kazuyoshi¹,Stamford Andrew¹,Foley Michael¹,Meinke Peter T.¹,Nathan Carl,Bryk Ruslana^ORCID

Affiliation:

1. Tri-Institutional Therapeutics Discovery Institute, New York, New York 10065, United States

2. Structural Biology Program, Sloan Kettering Institute, New York, New York 10065, United States

3. Howard Hughes Medical Institute, New York, New York 10065, United States

Funder

National Cancer Institute

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

http://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.0c00788

Reference27 articles.

1. WHO. Global Tuberculosis Reports; WHO: https://www.who.int/tb/publications/global_report/en/, 2019.

2. Mycobacterium tuberculosis appears to lack α-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes

3. Virulence of Mycobacterium tuberculosis Depends on Lipoamide Dehydrogenase, a Member of Three Multienzyme Complexes

4. Peroxynitrite reductase activity of bacterial peroxiredoxins

5. Metabolic Enzymes of Mycobacteria Linked to Antioxidant Defense by a Thioredoxin-Like Protein

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors;ACS Bio & Med Chem Au;2023-09-08

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