Directed Evolution of the Nonribosomal Peptide Synthetase BpsA to Enable Recognition by the Human Phosphopantetheinyl Transferase for Counter-Screening Antibiotic Candidates-Reference-Cited by-同舟云学术

Directed Evolution of the Nonribosomal Peptide Synthetase BpsA to Enable Recognition by the Human Phosphopantetheinyl Transferase for Counter-Screening Antibiotic Candidates

Published:2020-10-29 Issue:11 Volume:6 Page:2879-2886
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Brown Alistair S.¹²³,Sissons Jack A.¹,Owen Jeremy G.¹²³,Ackerley David F.¹²³^ORCID

Affiliation:

1. School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand

2. Centre for Biodiscovery, School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand

3. Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand

Funder

Health Research Council of New Zealand

Royal Society of New Zealand

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.0c00606

Reference34 articles.

1. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life

2. Genetic characterization of pcpS, encoding the multifunctional phosphopantetheinyl transferase of Pseudomonas aeruginosa

3. 4′-Phosphopantetheinyl Transferase PptT, a New Drug Target Required for Mycobacterium tuberculosis Growth and Persistence In Vivo

4. 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a Potent Inhibitor of Bacterial Phosphopantetheinyl Transferase That Attenuates Secondary Metabolism and Thwarts Bacterial Growth

5. Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

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1. Directed Evolution of the BpsA Carrier Protein Domain for Recognition by Non-cognate 4′-Phosphopantetheinyl Transferases to Enable Inhibitor Screening;Methods in Molecular Biology;2023

2. Escherichia coli Nissle 1917 secondary metabolism: aryl polyene biosynthesis and phosphopantetheinyl transferase crosstalk;Applied Microbiology and Biotechnology;2021-09-21

3. Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the Essential Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT;Pharmaceutics;2021-07-12