Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity

Author:

Tavella Tatyana Almeida1,da Silva Noeli Soares Melo2,Spillman Natalie3,Kayano Ana Carolina Andrade Vitor1,Cassiano Gustavo Capatti14,Vasconcelos Adrielle Ayumi5,Camargo Antônio Pedro5,da Silva Djane Clarys Baia67,Fontinha Diana8,Salazar Alvarez Luis Carlos1,Ferreira Letícia Tiburcio1,Peralis Tomaz Kaira Cristina1,Neves Bruno Junior910ORCID,Almeida Ludimila Dias11,Bargieri Daniel Youssef12,Lacerda Marcus Vinicius Guimarães de7,Lemos Cravo Pedro Vitor104,Sunnerhagen Per13ORCID,Prudêncio Miguel8,Andrade Carolina Horta19,Pinto Lopes Stefanie Costa67,Carazzolle Marcelo Falsarella5,Tilley Leann3ORCID,Bilsland Elizabeth11,Borges Júlio César2ORCID,Maranhão Costa Fabio Trindade1ORCID

Affiliation:

1. Laboratory of Tropical Diseases−Prof. Dr. Luiz Jacinto da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas−UNICAMP, Campinas, SP 13083-970, Brazil

2. Biochemistry and Biophysics of Proteins Group−São Carlos Institute of Chemistry−IQSC, University of São Paulo, Trabalhador Sancarlense Avenue, 400, BQ1, S27, São Carlos, SP 13566-590, Brazil

3. Department of Biochemistry, Bio 21 Institute, University of Melbourne, 30 Flemington Rd, Parkville, Melbourne,VIC 3052, Australia

4. Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1099-085 Lisboa, Portugal

5. Laboratory of Genomics and BioEnergy, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas−UNICAMP, Campinas, SP 13083-970, Brazil

6. Leônidas & Maria Deane Institute, Fundação Oswaldo Cruz−FIOCRUZ, Manaus , AM 69057070, Brazil

7. Fundação de Medicina Tropical−Dr. Heitor Vieira Dourado, Manaus, AM 69040-000, Brazil

8. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisboa, Portugal

9. Laboratory of Molecular Modeling and Drug Design, LabMol, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO 74605-170, Brazil

10. LabChem−Laboratory of Cheminformatics, Centro Universitário de Anápolis−UniEVANGÉLICA, Anápolis, GO 75083-515, Brazil

11. Synthetic Biology Laboratory, Department of Structural and Functional Biology, Institute of Biology, UNICAMP, Campinas, SP Brazil

12. Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Cidade Universitária “Armando Salles Oliveira”, São Paulo 05508-000, Brazil

13. Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Gothenburg, Sweden

Funder

Funda????o Oswaldo Cruz

Instituto Serrapilheira

Funda????o de Amparo ?? Pesquisa do Estado de Goi??s

Funda????o de Amparo ?? Pesquisa do Estado do Amazonas

Minist??rio da Ci??ncia, Tecnologia e Inova????o

Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo

Minist??rio da Educa????o e Ci??ncia

Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior

Swedish Research Council

Australian National Health and Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Reference84 articles.

1. World Health Organization. World Malaria Report 2019; Geneva, 2019.

2. Malaria: Biology and Disease

3. The Next Opportunity in Anti-Malaria Drug Discovery: The Liver Stage

4. Antimalarial Transmission-Blocking Interventions: Past, Present, and Future

5. Malaria: Strategy Overview; Bill Melinda Gates Foundation, 2011; April, pp 1–6.

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