Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity

Author:

Yarlagadda Venkateswarlu1,Medina Ricardo2,Johnson Timothy A.3,Koteva Kalinka P.1,Cox Georgina4ORCID,Thaker Maulik N.5,Wright Gerard D.1ORCID

Affiliation:

1. David Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada

2. Department of Microbiology, Chemical Bioactive Center, Central University Marta Abreu de las Villas, Santa Clara 54830, Villa Clara, Cuba

3. Department of Animal Sciences, Purdue University College of Agriculture, West Lafayette, Indiana 47907, United States

4. Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada

5. Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

Funder

Canadian Institutes of Health Research

Canada Research Chairs

Ontario Research Fund

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Reference51 articles.

1. O’Neill, J. (2016) Tackling Drug-Resistant Infections Globally: Final Report and Recommendations.

2. Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future

3. World Health Organization. Antibiotic-resistant gonorrhoea on the rise, new drugs needed. https://www.who.int/news-room/detail/07-07-2017-antibiotic-resistant-gonorrhoea-on-the-rise-new-drugs-needed (accessed July 2, 2020).

4. The novel 2016 WHONeisseria gonorrhoeaereference strains for global quality assurance of laboratory investigations: phenotypic, genetic and reference genome characterization

5. Multidrug-resistant and extensively drug-resistant Neisseria gonorrhoeae in Canada, 2012–2016

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