Discovery of Cephalosporin-3′-Diazeniumdiolates That Show Dual Antibacterial and Antibiofilm Effects against Pseudomonas aeruginosa Clinical Cystic Fibrosis Isolates and Efficacy in a Murine Respiratory Infection Model

Author:

Rineh Ardeshir12,Soren Odel345,McEwan Timothy12,Ravikumar Vikashini6,Poh Wee Han6,Azamifar Fereshteh17,Naimi-Jamal M. Reza7ORCID,Cheung Chen-Yi8,Elliott Alysha G.9ORCID,Zuegg Johannes9,Blaskovich Mark A. T.9ORCID,Cooper Matthew A.9ORCID,Dolange Victoria5,Christodoulides Myron5,Cook Gregory M.810,Rice Scott A.61112ORCID,Faust Saul N.4513,Webb Jeremy S.3413,Kelso Michael J.12ORCID

Affiliation:

1. Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales 2522, Australia

2. Illawarra Health and Medical Research Institute, Wollongong, New South Wales 2522, Australia

3. Biological Sciences and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom

4. National Biofilm Innovation Centre, University of Southampton, Southampton SO17 1BJ, United Kingdom

5. Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO16 6YD, United Kingdom

6. Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, 637551, Singapore

7. Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran

8. Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand

9. Community for Open Antimicrobial Drug Discovery, Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia

10. Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1042, New Zealand

11. ithree Institute, University of Technology Sydney, Ultimo, New South Wales 2007, Australia

12. School of Biological Sciences, Nanyang Technological University, 637551, Singapore

13. NIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, United Kingdom

Funder

Ministry of Education - Singapore

National Institute for Health Research

National Health and Medical Research Council

Health Research Council of New Zealand

National Research Foundation Singapore

Wellcome Trust

Australian Cystic Fibrosis Research Trust

National University of Singapore

Nanyang Technological University

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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