Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity

Author:

Evans Joanna C.1ORCID,Murugesan Dinakaran2,Post John M.2,Mendes Vitor3ORCID,Wang Zhe4,Nahiyaan Navid4,Lynch Sasha L.1,Thompson Stephen2,Green Simon R.2ORCID,Ray Peter C.2,Hess Jeannine5,Spry Christina5ORCID,Coyne Anthony G.5ORCID,Abell Chris5ORCID,Boshoff Helena I. M.6ORCID,Wyatt Paul G.2ORCID,Rhee Kyu Y.4,Blundell Tom L.3,Barry Clifton E.16,Mizrahi Valerie1ORCID

Affiliation:

1. MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, South Africa

2. Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K.

3. Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, U.K.

4. Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States

5. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

6. Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States

Funder

Howard Hughes Medical Institute

Medical Research Council

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

National Institute of Allergy and Infectious Diseases

National Health and Medical Research Council

H2020 Marie Sklodowska-Curie Actions

Bill and Melinda Gates Foundation

Wellcome Trust

National Research Foundation

South African Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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