Novel Nonsubstrate Inhibitors of Human Thymidine Phosphorylase, a Potential Target for Tumor-Dependent Angiogenesis-Reference-Cited by-同舟云学术

Novel Nonsubstrate Inhibitors of Human Thymidine Phosphorylase, a Potential Target for Tumor-Dependent Angiogenesis

Published:2000-06-01 Issue:13 Volume:43 Page:2601-2607
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Focher Federico¹,Ubiali Daniela¹,Pregnolato Massimo¹,Zhi Chengxin¹,Gambino Joseph¹,Wright George E.¹,Spadari Silvio¹

Affiliation:

1. Istituto di Genetica Biochimica ed Evoluzionistica, CNR, via Abbiategrasso 207, I-27100 Pavia, Italy, Dipartimento di Chimica Farmaceutica, Università degli Studi, via Taramelli 12, I-27100 Pavia, Italy, and GLSynthesis Inc., One Innovation Drive, Worcester, Massachusetts 01605

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000037u

Reference34 articles.

1. What Is the Evidence That Tumors Are Angiogenesis Dependent?

2. Thymidine phosphorylase is angiogenic and promotes tumor growth.

3. Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets

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