Potent and Selective Inhibitors of PDGF Receptor Phosphorylation. 2. Synthesis, Structure Activity Relationship, Improvement of Aqueous Solubility, and Biological Effects of 4-[4-(N-Substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline Derivatives-Reference-Cited by-同舟云学术

Potent and Selective Inhibitors of PDGF Receptor Phosphorylation. 2. Synthesis, Structure Activity Relationship, Improvement of Aqueous Solubility, and Biological Effects of 4-[4-(N-Substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline Derivatives

Published:2002-08-27 Issue:20 Volume:45 Page:4513-4523
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Matsuno Kenji¹,Nakajima Takao¹,Ichimura Michio¹,Giese Neill A.¹,Yu Jin-Chen¹,Lokker Nathalie A.¹,Ushiki Junko¹,Ide Shin-ichi¹,Oda Shoji¹,Nomoto Yuji¹

Affiliation:

1. Kyowa Hakko Kogyo Co., Ltd., Pharmaceutical Research Institute, Shimotogari 1188, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8731, Japan, and Millennium Pharmaceuticals, Inc., 256 E. Grand Avenue, South San Francisco, California 94080

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0201114

Reference37 articles.

1. Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.

2. Platelet-derived growth factor: Isoform-specific signalling via heterodimeric or homodimeric receptor complexes

3. Dimerization of extracellular domains of platelet-derived growth factor receptors. A revised model of receptor-ligand interaction

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