1. Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan, Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Kita 21 Nishi 11, Sapporo 001-0021, Japan, School of Pharmacy, Iwate Medical University, Nishitokuta, Yahaba, Iwate 028-3694, Japan, and Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan