Effects of the Oncogenic V664E Mutation on Membrane Insertion, Structure, and Sequence-Dependent Interactions of the Neu Transmembrane Domain in Micelles and Model Membranes: An Integrated Biophysical and Simulation Study-Reference-Cited by-同舟云学术

Effects of the Oncogenic V664E Mutation on Membrane Insertion, Structure, and Sequence-Dependent Interactions of the Neu Transmembrane Domain in Micelles and Model Membranes: An Integrated Biophysical and Simulation Study

Published:2012-03-14 Issue:12 Volume:51 Page:2558-2568
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Beevers Andrew J.,Nash Anthony,Salazar-Cancino Martha,Scott David J.¹,Notman Rebecca,Dixon Ann M.

Affiliation:

1. Department of Biosciences, University of Nottingham, Nottingham, U.K.

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi201269w

Reference48 articles.

1. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

2. Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.

3. Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion.

4. A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

5. Sequence-Dependent Oligomerization of the Neu Transmembrane Domain Suggests Inhibition of “Conformational Switching” by an Oncogenic Mutant

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