Aminoethylenes: A Tetrahedral Intermediate Isostere Yielding Potent Inhibitors of the Aspartyl Protease BACE-1-Reference-Cited by-同舟云学术

Aminoethylenes: A Tetrahedral Intermediate Isostere Yielding Potent Inhibitors of the Aspartyl Protease BACE-1

Published:2006-01-12 Issue:3 Volume:49 Page:839-842
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Wenjin¹,Lu Wanli¹,Lu Yafan¹,Zhong Min¹,Sun Jian¹,Thomas Anila E.¹,Wilkinson Jennifer M.¹,Fucini Raymond V.¹,Lam Melissa¹,Randal Mike¹,Shi Xiao-Ping¹,Jacobs Jeffrey W.¹,McDowell Robert S.¹,Gordon Eric M.¹,Ballinger Marcus D.¹

Affiliation:

1. Departments of Chemistry, Biochemistry, and Structural Biology, Sunesis Pharmaceuticals, Incorporated, 341 Oyster Point Boulevard, South San Francisco, California 94080, and Department of Alzheimer's Research, Merck Research Laboratories, P.O. Box 4, West Point, Pennsylvannia 19486

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0509142

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4. Erickson, J. W.; Eissenstat, M. A. HIV Protease as a Target for the Design of Antiviral Agents for AIDS.Proteases of Infectious Agents; Academic Press: San Diego, London, 1999; pp 1−60.

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