New 7-Methylguanine Derivatives Targeting the Influenza Polymerase PB2 Cap-Binding Domain

Author:

Pautus Stéphane12,Sehr Peter3,Lewis Joe3,Fortuné Antoine1,Wolkerstorfer Andrea4,Szolar Oliver4,Guilligay Delphine2,Lunardi Thomas2,Décout Jean-Luc1,Cusack Stephen2

Affiliation:

1. Département de Pharmacochimie Moléculaire, Université de Grenoble Alpes/CNRS, UMR 5063, ICMG FR 2607, 470 rue de la Chimie, BP 53, F-38041 Grenoble, France

2. Grenoble Outstation, European Molecular Biology Laboratory and Univ. Alpes-Grenoble-EMBL-CNRS Unit for Virus Host Cell Interactions, 6 rue Jules Horowitz, BP181, F-38042 Grenoble Cedex 9, France

3. Chemical Biology Core Facility, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

4. Savira pharmaceuticals GmbH, Vienna, Austria

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference34 articles.

1. Global Patterns of Influenza A Virus in Wild Birds

2. Chen, Y.; Liang, W.; Yang, S.; Wu, N.; Gao, H.; Sheng, J.; Yao, H.; Wo, J.; Fang, Q.; Cui, D.; Li, Y.; Yao, X.; Zhang, Y.; Wu, H.; Zheng, S.; Diao, H.; Xia, S.; Chan, K. H.; Tsoi, H. W.; Teng, J. L.; Song, W.; Wang, P.; Lau, S. Y.; Zheng, M.; Chan, J. F.; K., K.; Chen, H.; Li, L.; Yuen, K. Y.Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome.Lancet 2013.

3. The Potential for Respiratory Droplet–Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host

4. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

5. Influenza: lessons from past pandemics, warnings from current incidents

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