Design and Synthesis of 5,5′-Disubstituted Aminohydantoins as Potent and Selective Human β-Secretase (BACE1) Inhibitors-Reference-Cited by-同舟云学术

Design and Synthesis of 5,5′-Disubstituted Aminohydantoins as Potent and Selective Human β-Secretase (BACE1) Inhibitors

Published:2009-12-07 Issue:3 Volume:53 Page:1146-1158
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Malamas Michael S.¹,Erdei Jim¹,Gunawan Iwan¹,Turner Jim²,Hu Yun²,Wagner Erik²,Fan Kristi¹,Chopra Rajiv³,Olland Andrea³,Bard Jonathan²,Jacobsen Steve²,Magolda Ronald L.¹,Pangalos Menelas²,Robichaud Albert J.¹

Affiliation:

1. Department of Chemical Sciences, Wyeth Research, CN 8000, Princeton, New Jersey 08543-8000

2. Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543-8000

3. Department of Chemical Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901414e

Reference61 articles.

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2. Alzheimer's disease: a review of the disease, its epidemiology and economic impact

3. Chapter 53: Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease

4. Economics of dementia and pharmacoeconomics of dementia therapy

5. Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization

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