Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement-Reference-Cited by-同舟云学术

Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

Published:2003-05-13 Issue:12 Volume:46 Page:2275-2278
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Churcher Ian¹,Williams Susie¹,Kerrad Sonia¹,Harrison Timothy¹,Castro José L.¹,Shearman Mark S.¹,Lewis Huw D.¹,Clarke Earl E.¹,Wrigley Jonathan D. J.¹,Beher Dirk¹,Tang Yui S.¹,Liu Wensheng¹

Affiliation:

1. Department of Medicinal Chemistry and Department of Biochemistry & Molecular Biology, The Neuroscience Research Centre, Merck Sharp & Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, U.K., and Department of Drug Metabolism, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm034058a

Reference31 articles.

1. β-Amyloid therapies in Alzheimer’s disease

2. Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease

3. The Solved and Unsolved Mysteries of the Genetics of Early-Onset Alzheimer 's Disease

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5. The multiple paradoxes of presenilins

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