Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors

Author:

Mistry Shailesh N.1,Drinkwater Nyssa2,Ruggeri Chiara23,Sivaraman Komagal Kannan2,Loganathan Sasdekumar4,Fletcher Sabine4,Drag Marcin5,Paiardini Alessandro3,Avery Vicky M.4,Scammells Peter J.1,McGowan Sheena2

Affiliation:

1. Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia

2. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia

3. Dipartmento di Scienze Biochimiche “A. Rossi Fanelli”, Sapienza Universita di Roma, 00185 Roma, Italy

4. Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia

5. Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland

Funder

National Health and Medical Research Council

Australian Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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