1. College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan, Republic of China, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, Republic of China, Institute of Cancer Research, National Health Research Institutes, Taipei 114, Taiwan, Republic of China, and Divison of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan, Republic of China