1. Division of Nephrology, Department of Internal Medicine, Show-Chwan Memorial Hospital, Changhua, Taiwan, Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, Institute of Biochemistry and Biotechnology, Medical College, Chung Shan Medical University, Taichung, Taiwan, and Department of Pathology and Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan