1. The Department of Geriatrics, Ren-Ji Hospital, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai 200001, China, The Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, SJTU-SM Shanghai 200001, China, Department of Pathology, SJTU-SM, Shanghai 200025, China, and Institute of Health Sciences, Shanghai Institutes for Biological Sciences-SJTU-SM, Shanghai 200025, China