Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors-Reference-Cited by-同舟云学术

Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors

Published:2008-10-23 Issue:22 Volume:51 Page:7049-7052
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ramurthy Savithri¹,Subramanian Sharadha¹,Aikawa Mina¹,Amiri Payman¹,Costales Abran¹,Dove Jeff¹,Fong Susan¹,Jansen Johanna M.¹,Levine Barry¹,Ma Sylvia¹,McBride Christopher M.¹,Michaelian Jonah¹,Pick Teresa¹,Poon Daniel J.¹,Girish Sandhya¹,Shafer Cynthia M.¹,Stuart Darrin¹,Sung Leonard¹,Renhowe Paul A.¹

Affiliation:

1. Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, California 94608

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801050k

Reference23 articles.

1. Protein Kinase A Blocks Raf-1 Activity by Stimulating 14-3-3 Binding and Blocking Raf-1 Interaction with Ras

2. Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

3. Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

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