N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands Have Selective Antiproliferative Effects on Cancer Cells and Induce Telomere Damage-Reference-Cited by-同舟云学术

N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands Have Selective Antiproliferative Effects on Cancer Cells and Induce Telomere Damage

Published:2011-01-31 Issue:5 Volume:54 Page:1140-1156
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Casagrande Valentina¹,Salvati Erica²,Alvino Antonello¹,Bianco Armandodoriano¹,Ciammaichella Alina¹,D’Angelo Carmen²,Ginnari-Satriani Luca¹,Serrilli Anna Maria¹,Iachettini Sara²,Leonetti Carlo²,Neidle Stephen³,Ortaggi Giancarlo¹,Porru Manuela²,Rizzo Angela²,Franceschin Marco¹,Biroccio Annamaria²

Affiliation:

1. Dipartimento di Chimica, Università degli Studi “La Sapienza”, P.le A. Moro 5, 00185 Roma, Italy

2. Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d’Oro 156, 00158 Rome, Italy

3. Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1013665

Reference43 articles.

1. Quadruplex DNA: sequence, topology and structure

2. Quadruplex DNA crystal structures and drug design

3. Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo

4. Preferential binding of a G-quadruplex ligand to human chromosome ends

5. Telomere maintenance as a target for anticancer drug discovery

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