N-Methylation of the C3′ Amide of Taxanes: Synthesis of N-Methyltaxol C and N-Methylpaclitaxel
Author:
Affiliation:
1. Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jo800173h
Reference11 articles.
1. Vyas, D. M.InThe Chemistry and Pharmacology of Taxol® and its Derivatives;Farina, V., Ed;Elsevier:Amsterdam,1995; pp103−130.
2. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
3. Syntheses and Structure−Activity Relationships of the Second-Generation Antitumor Taxoids: Exceptional Activity against Drug-Resistant Cancer Cells
4. Chemical Modification of Paclitaxel (Taxol) Reduces P-Glycoprotein Interactions and Increases Permeation across the Blood−Brain Barrier in Vitro and in Situ
5. Improved biochemical strategies for targeted delivery of taxoids
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