Synthetic Transformations of Eleutherobin Reveal New Features of Its Microtubule-Stabilizing Pharmacophore-Reference-Cited by-同舟云学术

Synthetic Transformations of Eleutherobin Reveal New Features of Its Microtubule-Stabilizing Pharmacophore

Published:2001-08-10 Issue:35 Volume:123 Page:8632-8633
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Britton Robert¹,de Silva E. Dilip¹,Bigg Cristina M.¹,McHardy Lianne M.¹,Roberge Michel¹,Andersen Raymond J.¹

Affiliation:

1. Departments of Chemistry and EOS University of British Columbia Vancouver, British Columbia, Canada, V6T 1Z1 Department of Biochemistry and Molecular Biology University of British Columbia Vancouver, British Columbia, Canada, V6T 1Z3

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja016459q

Reference13 articles.

1. Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle

2. A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

3. A common pharmacophore for cytotoxic natural products that stabilize microtubules

4. Eleutherobin, a New Cytotoxin that Mimics Paclitaxel (Taxol) by Stabilizing Microtubules

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