Discovery of Sodium R-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor-Reference-Cited by-同舟云学术

Discovery of Sodium R-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

Published:2008-11-12 Issue:23 Volume:51 Page:7478-7485
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Chen¹,Wu Dongpei¹,Guo Zhiqiang¹,Xie Qiu¹,Reinhart Greg J.¹,Madan Ajay¹,Wen Jenny¹,Chen Takung¹,Huang Charles Q.¹,Chen Mi¹,Chen Yongsheng¹,Tucci Fabio C.¹,Rowbottom Martin¹,Pontillo Joseph¹,Zhu Yun-Fei¹,Wade Warren¹,Saunders John¹,Bozigian Haig¹,Struthers R. Scott¹

Affiliation:

1. Department of Medicinal Chemistry, Department of Endocrinology, and Department of Preclinical Development, Neurocrine Biosciences, Inc., 12790 El Camino Real, San Diego, California 92130

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8006454

Reference26 articles.

1. Primary Structure of the Ovine Hypothalamic Luteinizing Hormone-Releasing Factor (LRF)

2. Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence

3. Gonadotropin-Releasing Hormone Receptors

4. The Molecular Basis of Gonadotropin-Releasing Hormone Action*

5. Gonadotropin-releasing-hormone-receptor antagonists

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