Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B-Reference-Cited by-同舟云学术

Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B

Published:2015-02-26 Issue:5 Volume:58 Page:2553-2559
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Drouin Ludovic¹,McGrath Sally¹,Vidler Lewis R.¹,Chaikuad Apirat²,Monteiro Octovia²³,Tallant Cynthia²³,Philpott Martin²³,Rogers Catherine²³,Fedorov Oleg²³,Liu Manjuan¹,Akhtar Wasim¹,Hayes Angela¹,Raynaud Florence¹,Müller Susanne²³,Knapp Stefan²³,Hoelder Swen¹

Affiliation:

1. The Institute of Cancer Research, Division of Cancer Therapeutics, Cancer Research UK Cancer Therapeutics Unit, 15 Cotswold Road, Sutton, London SM2 5NG, U.K.

2. The Structural Genomic Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, U.K.

3. Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Headington, Oxford OX3 7FZ, U.K.

Funder

Engineering and Physical Sciences Research Council

Wellcome Trust

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501963e

Reference24 articles.

1. Targeting bromodomains: epigenetic readers of lysine acetylation

2. Bromodomains as therapeutic targets

3. Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

4. Recognizing and exploiting differences between RNAi and small-molecule inhibitors

5. A Novel Family of Bromodomain Genes

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