New, Azide-Free Transformation of Epoxides into 1,2-Diamino Compounds: Synthesis of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu)-Reference-Cited by-同舟云学术

New, Azide-Free Transformation of Epoxides into 1,2-Diamino Compounds: Synthesis of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu)

Published:2001-02-24 Issue:6 Volume:66 Page:2044-2051
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Karpf Martin¹,Trussardi René¹

Affiliation:

1. F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Non-Clinical Development, Chemical Process Research, Grenzacherstrasse 124, CH-4070, Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo005702l

Reference19 articles.

1. Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors

2. Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site: Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity

3. The synthesis of 2,3-didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid: a potent influenza virus sialidase inhibitor

4. Rational design of potent sialidase-based inhibitors of influenza virus replication

5. Molecular Modeling Studies on Ligand Binding to Sialidase from Influenza Virus and the Mechanism of Catalysis

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