1. Institute of Biochemistry, University of Leipzig, 04103 Leipzig, Germany, Helmholtz Centre for Environmental Research - UFZ, Department of Metabolomics, 04318 Leipzig, Germany, Helmholtz Centre for Environmental Research - UFZ, Department of Proteomics, 04318 Leipzig, Germany, Institute of Pharmaceutical and Medicinal Chemistry, University of Freiburg, 79104 Freiburg, Germany, and Department of Biotechnology, Delft University of Technology, The Netherlands