Discovery of the First Potent and Selective Small Molecule Opioid Receptor-like (ORL1) Antagonist: 1-[(3R,4R)-1-Cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl- 1,3-dihydro-2H-benzimidazol-2-one (J-113397)-Reference-Cited by-同舟云学术

Discovery of the First Potent and Selective Small Molecule Opioid Receptor-like (ORL1) Antagonist: 1-[(3R,4R)-1-Cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl- 1,3-dihydro-2H-benzimidazol-2-one (J-113397)

Published:1999-11-19 Issue:25 Volume:42 Page:5061-5063
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kawamoto Hiroshi¹,Ozaki Satoshi¹,Itoh Yoshiki¹,Miyaji Mitsuru¹,Arai Sachie¹,Nakashima Hiroshi¹,Kato Tetsuya¹,Ohta Hisashi¹,Iwasawa Yoshikazu¹

Affiliation:

1. Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990517p

Reference27 articles.

1. ORL1, a novel member of the opioid receptor family

2. cDNA cloning and regional distribution of a novel member of the opioid receptor family

3. Negative regulation of T-cell adhesion and activation by CD43

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