Methylated Analogues of Methyl (R)-4-(3,4-Dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as Highly Potent κ-Receptor Agonists: Stereoselective Synthesis, Opioid-Receptor Affinity, Receptor Selectivity, and Functional Studies-Reference-Cited by-同舟云学术

Methylated Analogues of Methyl (R)-4-(3,4-Dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as Highly Potent κ-Receptor Agonists: Stereoselective Synthesis, Opioid-Receptor Affinity, Receptor Selectivity, and Functional Studies

Published:2001-07-24 Issue:17 Volume:44 Page:2814-2826
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Soukara Stella¹,Maier Christoph A.¹,Predoiu Ursula¹,Ehret Andreas¹,Jackisch Rolf¹,Wünsch Bernhard¹

Affiliation:

1. Pharmazeutisches Institut der Universität Freiburg, Hermann-Herder-Strasse 9, 79104 Freiburg i. Br., Germany, and Institut für Experimentelle und Klinische Pharmakologie und Toxikologie II, Hirnforschung, Hansastrasse 9A, D-79104 Freiburg, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0108395

Reference41 articles.

1. Lipophilic analogs of sparsomycin as strong inhibitors of protein synthesis and tumor growth: a structure-activity relationship study

2. Naphtho and benzo analogs of the .kappa. opioid agonist trans-(.+-.)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide

3. Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinolines: a novel class of very potent antinociceptive agents with varying degrees of selectivity for .kappa. and .mu. opioid receptors

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