1. Department of Cardiology and Clinical Pharmacology, The Queen Elizabeth Hospital, Adelaide, SA 5011, Australia, Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, SA 5000, Australia, Department of Clinical Pharmacology, Flinders University, Adelaide, SA 5042 Australia, and Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6009, Australia