Electrochemical Generation of Electrophilic Drug Metabolites: Characterization of Amodiaquine Quinoneimine and Cysteinyl Conjugates by MS, IR, and NMR-Reference-Cited by-同舟云学术

Electrochemical Generation of Electrophilic Drug Metabolites: Characterization of Amodiaquine Quinoneimine and Cysteinyl Conjugates by MS, IR, and NMR

Published:2008-03-25 Issue:4 Volume:21 Page:928-935
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Jurva Ulrik¹,Holmén Anders¹,Grönberg Gunnar¹,Masimirembwa Collen¹,Weidolf Lars¹

Affiliation:

1. AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx700400c

Reference32 articles.

1. Reactive metabolites and their role in drug reactions

2. Mechanism of Idiosyncratic Drug Reactions: Reactive Metabolites Formation, Protein Binding and the Regulation of the Immune System

3. Are Chemically Reactive Metabolites Responsible for Adverse Reactions to Drugs?

4. A Comprehensive Listing of Bioactivation Pathways of Organic Functional Groups

5. Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

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