1. Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC, Institute of Bioinformatics and Systems Biology and Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 30010, Taiwan, ROC, Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan, ROC, and Department of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan, ROC