A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region-Reference-Cited by-同舟云学术

A 2.13 Å Structure of E. coli Dihydrofolate Reductase Bound to a Novel Competitive Inhibitor Reveals a New Binding Surface Involving the M20 Loop Region

Published:2006-11-04 Issue:24 Volume:49 Page:6977-6986
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Summerfield Rachael L.¹,Daigle Denis M.¹,Mayer Stanislas¹,Mallik Debasis¹,Hughes Donald W.¹,Jackson Sean G.¹,Sulek Margaret¹,Organ Michael G.¹,Brown Eric D.¹,Junop Murray S.¹

Affiliation:

1. Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3, Canada, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, Massachusetts 02139, Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada, Department of Chemistry, McMaster University, 1200 Main Street West, Hamilton, Ontario L8S 4M1, Canada, and Department of Biochemistry and Biomedical Sciences, McMaster...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060570v

Reference20 articles.

1. NEW INSIGHTS INTO ERYTHROPOIESIS: The Roles of Folate, Vitamin B12, and Iron

2. Vitamin B12-Folate Interrelationships

3. The methotrexate story: A paradigm for development of cancer chemotherapeutic agents

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