Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through Application of an “Agreement Docking” Method-Reference-Cited by-同舟云学术

Design and Synthesis of New Nonsteroidal Glucocorticoid Modulators through Application of an “Agreement Docking” Method

Published:2005-06-16 Issue:14 Volume:48 Page:4507-4510
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Barker Mike¹,Clackers Margaret¹,Demaine Derek A.¹,Humphreys Davina¹,Johnston Michael J.¹,Jones Haydn T.¹,Pacquet Francois¹,Pritchard John M.¹,Salter Mark¹,Shanahan Stephen E.¹,Skone Philip A.¹,Vinader Victoria M.¹,Uings Iain¹,McLay Iain M.¹,Macdonald Simon J. F.¹

Affiliation:

1. ri CEDD, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050345y

Reference18 articles.

1. Schimmer, B. P.; Parker, K. L. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogues: inhibitors of the synthesis and actions of adrenocortical hormones. InGoodman & Gilman'sThe Pharmacological Basis of Therapeutics, 9th ed; Hardman, J. G., Limbird, L. E., Molinoff, P. B., Ruddon, R. W., Eds.; McGraw-Hill: New York, 1996; pp 1459−1485.

2. Therapeutic potential of selective modulators of nuclear receptor action

3. Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

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