Inhalation by Design: Novel Tertiary Amine Muscarinic M3 Receptor Antagonists with Slow Off-Rate Binding Kinetics for Inhaled Once-Daily Treatment of Chronic Obstructive Pulmonary Disease-Reference-Cited by-同舟云学术

Inhalation by Design: Novel Tertiary Amine Muscarinic M3 Receptor Antagonists with Slow Off-Rate Binding Kinetics for Inhaled Once-Daily Treatment of Chronic Obstructive Pulmonary Disease

Published:2011-09-20 Issue:19 Volume:54 Page:6888-6904
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Glossop Paul A.¹,Watson Christine A. L.¹,Price David A.¹,Bunnage Mark E.¹,Middleton Donald S.¹,Wood Anthony¹,James Kim¹,Roberts Dannielle¹,Strang Ross S.¹,Yeadon Michael¹,Perros-Huguet Christelle¹,Clarke Nicholas P.¹,Trevethick Michael A.¹,Machin Ian¹,Stuart Emilio F.¹,Evans Steven M.¹,Harrison Anthony C.¹,Fairman David A.¹,Agoram Balaji¹,Burrows Jane L.¹,Feeder Neil¹,Fulton Craig K.¹,Dillon Barry R.¹,Entwistle David A.¹,Spence Fiona J.¹

Affiliation:

1. Department of Worldwide Medicinal Chemistry, ‡Allergy and Respiratory Research Unit, §Department of Pharmacokinetics, Dynamics and Metabolism, ⊥Department of Pharmaceutical Sciences, and ▽̂Department of Drug Safety, Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Kent CT13 9NJ, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200884j

Reference37 articles.

1. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

2. Tiotropium bromide: A novel once-daily anticholinergic bronchodilator for the treatment of COPD

3. Role of the Parasympathetic System in Airway Obstruction Due to Emphysema

4. Muscarinic acetylcholine receptors and airway diseases

5. Potential for long-acting muscarinic antagonists in chronic obstructive pulmonary disease

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