N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation-Reference-Cited by-同舟云学术

N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation

Published:2009-04-07 Issue:9 Volume:52 Page:2794-2798
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nirschl Alexandra A.¹,Zou Yan¹,Krystek Stanley R.¹,Sutton James C.¹,Simpkins Ligaya M.¹,Lupisella John A.¹,Kuhns Joyce E.¹,Seethala Ramakrishna¹,Golla Rajasree¹,Sleph Paul G.¹,Beehler Blake C.¹,Grover Gary J.¹,Egan Donald¹,Fura Aberra¹,Vyas Viral P.¹,Li Yi-Xin¹,Sack John S.¹,Kish Kevin F.¹,An Yongmi¹,Bryson James A.¹,Gougoutas Jack Z.¹,DiMarco John¹,Zahler Robert¹,Ostrowski Jacek¹,Hamann Lawrence G.¹

Affiliation:

1. Discovery Chemistry, Molecular Biosciences, Discovery Biology, MAP Discovery, Discovery Analytical Sciences, Analytical Research & Development, Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801583j

Reference19 articles.

1. Andropause: Is Androgen Replacement Therapy Indicated for the Aging Male?

2. The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications

3. Muscle-Bound? A Tissue-Selective Nonsteroidal Androgen Receptor Modulator

4. Androgen regulation of β-amyloid protein and the risk of Alzheimer's disease

5. Discovery of a Potent, Orally Active, Nonsteroidal Androgen Receptor Agonist: 4-Ethyl-1,2,3,4-tetrahydro-6- (trifluoromethyl)-8-pyridono[5,6-g]- quinoline (LG121071)

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