The 2′-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor-Reference-Cited by-同舟云学术

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The 2′-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor

Published:2013-03-26 Issue:5 Volume:4 Page:486-490
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Blobaum Anna L.¹,Uddin Md. Jashim¹,Felts Andrew S.¹,Crews Brenda C.¹,Rouzer Carol A.¹,Marnett Lawrence J.¹

Affiliation:

1. The A. B. Hancock Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

Funder

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml400066a

Reference23 articles.

1. Mechanism of Action of Anti-Inflammatory Drugs

2. Cyclooxygenases: Structural, Cellular, and Molecular Biology

3. The COXIB Experience: A Look in the Rearview Mirror

4. Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs.

5. Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents.

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5. Synthesis and Computational Study of Some New 1-(1H-indol-1- yl)ethanone Derivatives on COX-2 Enzyme and Evaluation of In-Vivo Analgesic and Anti-inflammatory Activity;Letters in Drug Design & Discovery;2023-10

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