Inhibitors of Phenylethanolamine N-Methyltransferase That Are Predicted To Penetrate the Blood−Brain Barrier: Design, Synthesis, and Evaluation of 3-Fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines That Possess Low Affinity toward the α2-Adrenoceptor-Reference-Cited by-同舟云学术

Inhibitors of Phenylethanolamine N-Methyltransferase That Are Predicted To Penetrate the Blood−Brain Barrier: Design, Synthesis, and Evaluation of 3-Fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines That Possess Low Affinity toward the α2-Adrenoceptor

Published:2004-08-01 Issue:18 Volume:47 Page:4483-4493
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Romero F. Anthony¹,Vodonick Steven M.¹,Criscione Kevin R.¹,McLeish Michael J.¹,Grunewald Gary L.¹

Affiliation:

1. Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, and College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0400653

Reference35 articles.

1. This work was presented at the 223rd National Meeting of the American Chemical Society in Orlando, FL, April 7−11, 2002 (MEDI-16) and at the 5th Winter Conference on Medicinal and Bioorganic Chemistry, Steamboat Springs, CO, January 26−31, 2003. The contents of this paper were taken in large part from the M.S. thesis (University of Kansas, 2000) and Ph.D. dissertation (University of Kansas, 2004) of F.A.R.

2. Purification and Properties of Phenylethanolamine-N-methyl Transferase

3. The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs

4. Blood-Brain Barrier for Adrenaline

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