The Gene calC Encodes for a Non-Heme Iron Metalloprotein Responsible for Calicheamicin Self-Resistance in Micromonospora-Reference-Cited by-同舟云学术

The Gene calC Encodes for a Non-Heme Iron Metalloprotein Responsible for Calicheamicin Self-Resistance in Micromonospora

Published:2000-02-01 Issue:7 Volume:122 Page:1556-1557
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Whitwam Ross E.¹,Ahlert Joachim¹,Holman Theodore R.¹,Ruppen Mark¹,Thorson Jon S.¹

Affiliation:

1. Laboratory for Biosynthetic Chemistry Memorial Sloan-Kettering Cancer Center 1275 York Avenue, Box 309, New York, New York 10021 Departments of Chemistry and Biochemistry University of California, Santa Cruz, California 95064 Wyeth-Ayerst Research Division of American Home Products, 401 North Middletown Road Pearl River, New York 10965

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja993612w

Reference30 articles.

1. (a) Lee, M. D.Enediyne Antibiotics as Antitumor Agents; Marcel Dekker: New York, 1995; pp 49−74.

2. Calicheamicin γ 1 I : an Antitumor Antibiotic That Cleaves Double-Stranded DNA Site Specifically

3. (a) Ellestad, G. A.; Ding, W.D.; Zein, N.; Townsend, C. A.Enediyne Antibioticsas Antitumor Agents; Marcel Dekker: New York, 1995; pp 137−160.

4. The carbohydrate domain of calicheamicin gamma I1 determines its sequence specificity for DNA cleavage.

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