Secosteroid Mechanism-Based Inactivators and Site-Directed Mutagenesis as Probes for Steroid Hormone Recognition by 3.alpha.-Hydroxysteroid Dehydrogenase-Reference-Cited by-同舟云学术

Secosteroid Mechanism-Based Inactivators and Site-Directed Mutagenesis as Probes for Steroid Hormone Recognition by 3.alpha.-Hydroxysteroid Dehydrogenase

Published:1994-08-30 Issue:34 Volume:33 Page:10367-10374
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Schlegel Brian P.,Pawlowski John E.,Hu Yuefei,Scolnick Daniel M.,Covey Douglas F.,Penning Trevor M.

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi00200a017

Reference31 articles.

1. The kinetic mechanism catalysed by homogeneous rat liver 3α-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs

2. Mechanism-based inactivation of 17.beta.,20.alpha.-hydroxysteroid dehydrogenase by an acetylenic secoestradiol

3. Irreversible active-site-directed inhibition of Δ5-3-ketosteroid isomerase by steroidal 17-β-oxiranes. Evidence for two modes of binding in steroid-enzyme complexes

4. Modification of an enzyme carboxylate residue in the inhibition of 3-oxo-.DELTA.5-steroid isomerase by (3S)-spiro[5.alpha.-androstane-3,2'-oxirane]-17.beta.-ol. Implications for the mechanism of action

5. Molecular Cloning and Expression of Rat Liver 3α-Hydroxysteroid Dehydrogenase

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