Hydroxy-1,2,5-oxadiazolyl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Pharmacological Characterization of γ-Aminobutyric Acid (GABA) Related Compounds-Reference-Cited by-同舟云学术

Hydroxy-1,2,5-oxadiazolyl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Pharmacological Characterization of γ-Aminobutyric Acid (GABA) Related Compounds

Published:2006-06-21 Issue:14 Volume:49 Page:4442-4446
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lolli Marco L.¹,Hansen Suzanne L.¹,Rolando Barbara¹,Nielsen Birgitte¹,Wellendorph Petrine¹,Madsen Karsten¹,Larsen Orla Miller¹,Kristiansen Uffe¹,Fruttero Roberta¹,Gasco Alberto¹,Johansen Tommy N.¹

Affiliation:

1. Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125 Torino, Italy, and Departments of Pharmacology and Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, DK-2100 Copenhagen, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm051288b

Reference21 articles.

1. Bioisosterism: A Rational Approach in Drug Design

2. Isosterism and molecular modification in drug design

3. Novel Class of Potent 4-Arylalkyl Substituted 3-Isoxazolol GABAA Antagonists: Synthesis, Pharmacology, and Molecular Modeling

4. Aspartate and Glutamate Mimetic Structures in Biologically Active Compounds

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