1. Institut Curie/CNRS, UMR 176, Bât. 110-112, Centre Universitaire, Orsay F-91405, France, Univ Paris-Sud, Orsay F-91405, France, and Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mail, Vancouver, BC V6T 1Z3, Canada sandrine.piguel@curie.u-psud.fr