Mithramycin Analogues Generated by Combinatorial Biosynthesis Show Improved Bioactivity-Reference-Cited by-同舟云学术

Mithramycin Analogues Generated by Combinatorial Biosynthesis Show Improved Bioactivity

Published:2008-01-15 Issue:2 Volume:71 Page:199-207
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Baig Irfan¹,Perez María¹,Braña Alfredo F.¹,Gomathinayagam Rohini¹,Damodaran Chendil¹,Salas Jose A.¹,Méndez Carmen¹,Rohr Jürgen¹

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, Kentucky 40536-0082, Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006, Spain, and Department of Clinical Sciences, College of Health Sciences, University of Kentucky, 900 South Limestone Street, Lexington, Kentucky 40536

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/np0705763

Reference36 articles.

1. The Biosynthesis of Aureolic Acid Group Antibiotics

2. Elucidation of the Glycosylation Sequence of Mithramycin Biosynthesis: Isolation of 3A-Deolivosylpremithramycin B and Its Conversion to Premithramycin B by Glycosyltransferase MtmGII

3. Characterization of Kinetics and Products of the Baeyer−Villiger Oxygenase MtmOIV, The Key Enzyme of the Biosynthetic Pathway toward the Natural Product Anticancer Drug Mithramycin from Streptomyces argillaceus

4. The structures of premithramycinone and demethylpremithramycinone, plausible early intermediates of the aureolic acid group antibiotic mithramycin

5. Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin

Cited by 50 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Digitoxose as powerful glycosyls for building multifarious glycoconjugates of natural products and un-natural products;Synthetic and Systems Biotechnology;2024-12

2. Mithramycin and its analogs: Molecular features and antitumor action;Pharmacology & Therapeutics;2024-08

3. Rational Engineering of Secondary Metabolic Pathways in a Heterologous Host to Enable the Biosynthesis of Hibarimicin Derivatives with Enhanced Anti-Melanomic Activity;Engineering;2024-07

4. Production of 130 diterpenoids by combinatorial biosynthesis in yeast;2023-03-24

5. Tetracycline natural products: discovery, biosynthesis and engineering;Chinese Journal of Natural Medicines;2022-10