Characterization and Optimization of Selective, Nonpeptidic Inhibitors of Cathepsin S with an Unprecedented Binding Mode-Reference-Cited by-同舟云学术

Characterization and Optimization of Selective, Nonpeptidic Inhibitors of Cathepsin S with an Unprecedented Binding Mode

Published:2007-05-01 Issue:11 Volume:50 Page:2693-2699
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Inagaki Hiroaki¹,Tsuruoka Hiroyuki¹,Hornsby Michael¹,Lesley Scott A.¹,Spraggon Glen¹,Ellman Jonathan A.¹

Affiliation:

1. Department of Chemistry, University of California, Berkeley, California 94720, and Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070111%2B

Reference18 articles.

1. Rapid Identification of Potent Nonpeptidic Serine Protease Inhibitors

2. Cathepsin S inhibitors

3. The role of cathepsins in osteoporosis and arthritis: Rationale for the design of new therapeutics

4. Thiol Proteases: Inhibitors and Potential Therapeutic Targets

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